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- Title
Clinical Transplantation and Tolerance: Are We There Yet?
- Authors
Saidi, R. F.; Hejazii Kenari, S. K.
- Abstract
Organ transplantation is not only considered as the last resort therapy but also as the treatment of choice for many patients with end-stage organ damage. Recipient-mediated acute or chronic immune response is the main challenge after transplant surgery. Nonspecific suppression of host immune system is currently the only method used to prevent organ rejection. Lifelong immunosuppression will cause significant side effects such as infections, malignancies, chronic kidney disease, hypertension and diabetes. This is more relevant in children who have a longer life expectancy so may receive longer period of immunosuppressive medications. Efforts to minimize or complete withdrawal of immunosuppression would improve the quality of life and long-term outcome of pediatric transplant recipients.
- Subjects
TOLERATION; LIVER transplantation; IMMUNE response; IMMUNOLOGY; DIABETES
- Publication
International Journal of Organ Transplantation Medicine, 2014, Vol 5, Issue 4, p137
- ISSN
2008-6490
- Publication type
Article