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- Title
Influence of gut microbiota on the development and progression of nonalcoholic steatohepatitis.
- Authors
de Faria Ghetti, Fabiana; Oliveira, Daiane Gonçalves; de Oliveira, Juliano Machado; de Castro Ferreira, Lincoln Eduardo Villela Vieira; Cesar, Dionéia Evangelista; Moreira, Ana Paula Boroni
- Abstract
Introduction: Nonalcoholic steatohepatitis (NASH) is characterized by the presence of steatosis, inflammation, and ballooning degeneration of hepatocytes, with or without fibrosis. The prevalence of NASH has increased with the obesity epidemic, but its etiology is multifactorial. The current studies suggest the role of gut microbiota in the development and progression of NASH. The aim is to review the studies that investigate the relationship between gut microbiota and NASH. These review also discusses the pathophysiological mechanisms and the influence of diet on the gut-liver axis.Result: The available literature has proposed mechanisms for an association between gut microbiota and NASH, such as: modification energy homeostasis, lipopolysaccharides (LPS)-endotoxemia, increased endogenous production of ethanol, and alteration in the metabolism of bile acid and choline. There is evidence to suggest that NASH patients have a higher prevalence of bacterial overgrowth in the small intestine and changes in the composition of the gut microbiota. However, there is still a controversy regarding the microbiome profile in this population. The abundance of Bacteroidetes phylum may be increased, decreased, or unaltered in NASH patients. There is an increase in the <italic>Escherichia</italic> and <italic>Bacteroides</italic> genus. There is depletion of certain taxa, such as <italic>Prevotella</italic> and <italic>Faecalibacterium</italic>.Conclusion: Although few studies have evaluated the composition of the gut microbiota in patients with NASH, it is observed that these individuals have a distinct gut microbiota, compared to the control groups, which explains, at least in part, the genesis and progression of the disease through multiple mechanisms. Modulation of the gut microbiota through diet control offers new challenges for future studies.
- Subjects
CHOLINE; DIET; ENERGY metabolism; ETHANOL; FATTY liver; HOMEOSTASIS; HOST-bacteria relationships; SMALL intestine; GUT microbiome; ENDOTOXEMIA; DISEASE progression
- Publication
European Journal of Nutrition, 2018, Vol 57, Issue 3, p861
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-017-1524-x