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- Title
Preparation of Water-Insoluble Antibacterial Materials with Surface-Grafted Material PSt/SiO and Their Antibacterial Activity.
- Authors
Gao, Baojiao; Liu, Qing; Li, Yanbin
- Abstract
Styrene (St) was graft-polymerized onto the surfaces of micro-sized silica gel particles, and the surface-grafted composite particles PSt/SiO were obtained. With the surface-grafted composite particles PSt/SiO as a starting material, water-insoluble antibacterial materials with quaternary 'onium' salt-type were synthesized via two polymer reaction steps. The grafted polystyrene was first chloromethylated, resulting in grafted particles CMPS/SiO, and then quaterisation (QN) and quaternary phosphonium reaction (QP) were conducted with triethylamine, tri- n-butylamine and triphenyl phosphine as reagents, respectively. Two kinds of water-insoluble antibacterial materials, QN-PSt/SiO and QP-PSt/SiO were prepared. Their antibacterial property was mainly investigated by using Escherichia coli ( E. coli) as a model bacterium and by adopting colony count method. The relationship between the chemical structure of the antibacterial group and antimicrobial activity for the water-insoluble antibacterial materials was studied in detail, and their antibacterial mechanism was investigated by TTC-dehydrogenase activity determination and extracellular DNA and RNA measurement methods. The experimental results show that QN-PSt/SiO and QP-PSt/SiO possess strong antibacterial activity. The main factors affecting the antibacterial ability of the water-insoluble materials are the chemical structure of the antibacterial groups, the bound density of the antibacterial groups on the surface of the water-insoluble antibacterial materials as well as the pH value of the medium. QP-PSt/SiO has stronger antibacterial activity than QN-PSt/SiO; the QN-PSt/SiO prepared with tri- n-butylamine has stronger antibacterial activity than that prepared with triethylamine; the water-insoluble material with higher bound density of the antibacterial groups has stronger antibacterial ability; as the pH value of the medium is over the isoelectric point of E. coli, the antibacterial ability is strengthened with the increase of pH value.
- Subjects
POLYSTYRENE; ANTIBACTERIAL agents; STYRENE; POLYMERIZATION; SILICA gel; ONIUM ions; ESCHERICHIA coli; CHEMICAL reagents; GRAFT copolymers
- Publication
Journal of Polymers & the Environment, 2010, Vol 18, Issue 4, p474
- ISSN
1566-2543
- Publication type
Article
- DOI
10.1007/s10924-010-0187-y