We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Current State and Future of Biologic Therapies in the Treatment of Asthma in Children.
- Authors
Abrams, Elissa M.; Becker, Allan B.; Szefler, Stanley J.
- Abstract
There is increasing recognition of phenotypic variability in pediatric asthma, providing the opportunity for a more personalized approach to therapy. Increasingly biologic therapies, in particular those targeting the "allergic" (or T helper 2) pathway, are being considered for children with severe asthma. However, there is a great deal of variability in the extent these biologic therapies have been studied in children, as well as efficacy of results thus far. The goal of this article is to review the mechanism of action, efficacy, and potential predictive and monitoring biomarkers of the biologic medications focusing on the pediatric population, in an effort to establish a more personalized approach to asthma in the pediatric population for the 21st century.
- Subjects
ASTHMA treatment; BIOMARKERS; BIOTHERAPY; TREATMENT effectiveness; INDIVIDUALIZED medicine; CHILDREN
- Publication
Pediatric Allergy, Immunology & Pulmonology, 2018, Vol 31, Issue 3, p119
- ISSN
2151-321X
- Publication type
Article
- DOI
10.1089/ped.2018.0901