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- Title
Poliovirus surveillance in patients with primary immunodeficiencies, India.
- Authors
Mohanty, Madhu Chhanda; Mohammad, Ahmad; Verma, Harish; Kumar, Arun; Madkaikar, Manisha Ranjan; Desai, Mukesh; Varose, Swapnil Yashwant; Sawant, Unnati; Yadav, Reetika Malik; Taur, Prasad; Kathuria, Rachana; Tatkare, Manogat; Murhekar, Megh; Haldarf, Pradeep; Abraham, Priya
- Abstract
Individuals with primary immunodeficiencies who are infected with vaccine-derived polioviruses may continue to shed poliovirus for months and go undetected by surveillance programmes of acute flaccid paralysis. These patients therefore pose a risk of initiating poliovirus outbreaks that jeopardize efforts towards global polio eradication. To identify these individuals, we designed a study protocol for the establishment of a network for surveillance of immunodeficiency-related vaccine-derived poliovirus in India. In the first step we identified recognized centres in India that could diagnose and enrol patients with primary immunodeficiency disorder into the study. Stool sample collection from study sites, culture, isolation, characterization of enteroviruses and reporting to study sites was carried out at the National Institute of Virology Mumbai Unit, as per the WHO national polio surveillance project protocol. In the first phase of the study from January 2020 to December 2021, we implemented the protocol at seven study sites at different medical institutes to determine the proportion of poliovirus infections in primary immunodeficiency disorder patients of India. We later expanded the study by including an additional 14 medical institutes across the country in the second phase running from January 2022 to December 2023. We believe this study protocol will help other countries to initiate immunodeficiency-related vaccine-derived poliovirus surveillance to identify and follow up patients who are long-term excretors of vaccine-derived poliovirus. Integration of immunodeficiency-related poliovirus surveillance with acute flaccid paralysis surveillance of the existing poliovirus network will enhance continuous screening of patients with primary immunodeficiency disorder in the future.
- Subjects
INDIA; POLIO prevention; IMMUNOLOGICAL deficiency syndrome complications; FECAL analysis; PRIMARY immunodeficiency diseases; PUBLIC health surveillance; ENTEROVIRUSES; POLIOMYELITIS vaccines; DISEASE eradication; MEDICAL screening; ACUTE flaccid paralysis; COLLECTION &; preservation of biological specimens; MEDICAL case management; MYELITIS
- Publication
Bulletin of the World Health Organization, 2023, Vol 101, Issue 5, p346
- ISSN
0042-9686
- Publication type
Article
- DOI
10.2471/BLT.22.289066