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- Title
Did the creeping vole sex chromosomes evolve through a cascade of adaptive responses to a selfish x chromosome?
- Authors
Roy, Scott William
- Abstract
The creeping vole Microtus oregoni exhibits remarkably transformed sex chromosome biology, with complete chromosome drive/drag, X‐Y fusions, sex reversed X complements, biased X inactivation, and X chromosome degradation. Beginning with a selfish X chromosome, I propose a series of adaptations leading to this system, each compensating for deleterious consequences of the preceding adaptation: (1) YY embryonic inviability favored evolution of a selfish feminizing X chromosome; (2) the consequent Y chromosome transmission disadvantage favored X‐Y fusion ("XP"); (3) Xist‐based silencing of Y‐derived XP genes favored a second X‐Y fusion ("XM"); (4) X chromosome dosage‐related costs in XPXM males favored the evolution of XM loss during spermatogenesis; (5) X chromosomal dosage‐related costs in XM0 females favored the evolution of XM drive during oogenesis; and (6) degradation of the non‐recombining XP favored the evolution of biased X chromosome inactivation. I discuss recurrent rodent sex chromosome transformation, and selfish genes as a constructive force in evolution.
- Subjects
X chromosome; Y chromosome; SEX chromosomes; SEX (Biology); VOLES; CHROMOSOMES; MICROTUS; GENE silencing; PLANT gene silencing
- Publication
BioEssays, 2023, Vol 45, Issue 12, p1
- ISSN
0265-9247
- Publication type
Article
- DOI
10.1002/bies.202100164