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- Title
Cover Feature: Biocatalytic and Regioselective Exchange of 2‐O‐Benzoyl for 2‐O‐(m‐Substituted)Benzoyl Groups to Make Precursors of Next‐Generation Paclitaxel Drugs (ChemCatChem 9/2024).
- Authors
Al‐Hilfi, Aimen; Li, Zhen; Merz, Kenneth M.; Nawarathne, Irosha N.; Walker, Kevin D.
- Abstract
The article titled "Biocatalytic and Regioselective Exchange of 2-O-Benzoyl for 2-O-(m-Substituted)Benzoyl Groups to Make Precursors of Next-Generation Paclitaxel Drugs" discusses a study conducted by researchers from Michigan State University and Lyon College. The study focuses on the development of a biocatalytic method to produce precursors for next-generation paclitaxel drugs. The researchers successfully demonstrated the regioselective exchange of 2-O-benzoyl groups for 2-O-(m-substituted)benzoyl groups using a biocatalyst. This research has potential implications for the synthesis of paclitaxel drugs, which are used in cancer treatment.
- Subjects
ALKALOIDS; PACLITAXEL; DRUGS
- Publication
ChemCatChem, 2024, Vol 16, Issue 9, p1
- ISSN
1867-3880
- Publication type
Article
- DOI
10.1002/cctc.202480903