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- Title
IgG4-Related Dacryoadenitis in Egyptian Patients: A Retrospective Study.
- Authors
Salama, Omar Hassan; Ibrahim, Ezzat Nabil Abbas; Hussein, Mostafa Osman; Alkady, Ahmed Mohammed Madinah; El-Salam, Mohammed Eid Abd; Ghanem, Saad
- Abstract
Purpose: To report clinical, serological, and histopathological findings in Egyptian patients with dacryoadenitis associated with ImmunoglobulinG4-related disease (IgG4-RD). Methods: We retrospectively revised medical records of patients presented to Al-Azhar University Hospitals with lacrimal gland (LG) swelling between June 2016 and February 2022. We included patients with definite IgG4-related disease (IgG4-RD) diagnosis and excluded those with possible, probable, or unlikely IgG4-RD based on The Japanese Ministry of Health, Labour, and Welfare's 2011 guidelines. Results: Sixteen cases were included in the study (Fourteen females and two males, mean age 39.2± 12.2 years); Seven cases met the criteria of Mikulicz disease, and nine cases met full clinical, serological, and histopathological criteria. Mean reported serum IgG was 1792.5 ± 313.7 (range 1063– 2134) mg/dl, mean serum IgG4 was 576.25± 215.3 (range 112– 841) mg/dl, and mean Serum IgG4/IgG ratio was 31.9 ± 12.4%. The mean number of IgG4+ plasma cells/HPF was 74 ± 21.2, and the mean IgG4+ plasma cell percentage was 55 ± 9.7%. Serum IgG4 level showed a positive correlation to tissue IgG4+plasma cell percentage, while serum IgG4/IgG ratio positively correlated to both percentage and number of IgG4+plasma cells. Steroids had a good initial response, but recurrences were common. Conclusion: A considerable proportion of patients with lacrimal gland swelling fall within the range of IgG4-RD. Proper diagnosis requires clinical, serological, and histopathologic correlation. Patients require long follow-up periods.
- Subjects
EGYPTIANS; JAMI'AT al-Azhar; LACRIMAL apparatus; PLASMA cells; UNIVERSITY hospitals; MEDICAL records
- Publication
Clinical Ophthalmology, 2022, Vol 16, p2765
- ISSN
1177-5467
- Publication type
Article
- DOI
10.2147/OPTH.S378583