We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Neuroprotective Effects of Valeriana wallichii on Scopolamine Induced Learning and Memory Impairment in Rats.
- Authors
Pathan, Aslam; Alshahrani, Abdulrahman
- Abstract
Objective: Alzheimer's disease (AD) is the most common cause of dementia in worldwide, treatment options is extremely limited and costly. The present study was conducted to investigate and validate the traditional claim of Valeriana wallichii on scopolamine treated rats as an AD model. Methods: The Valeriana wallichii rhizome ethanol extract (25 mg/kg/day) was administered daily along with scopolamine for a period of 14 days following which the elevated plus maze test were performed to assess learning and memory. Rats treated with scopolamine or vehicle only were also included in the experiment. Result: The study demonstrate that scopolamine treatment resulted in learning and memory deficits which were partially and significantly ameliorated by the Valeriana wallichii rhizome ethanol extract. Conclusion: The study demonstrates the ability of the Valeriana wallichii rhizome ethanol extract to reverse scopolamine-induced learning and memory deficits in rats.
- Subjects
NEUROPROTECTIVE agents; VALERIANACEAE; ALZHEIMER'S disease treatment; SCOPOLAMINE; MEMORY disorders
- Publication
Pharmacognosy Journal, 2018, Vol 23, Issue 6, pS38
- ISSN
0975-3575
- Publication type
Article
- DOI
10.5530/pj.2018.6s.7