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- Title
Correlation of basic fibroblast growth factor expression with the invasion and the prognosis of oral squamous cell carcinoma.
- Authors
Hase, Takashi; Kawashiri, Shuichi; Tanaka, Akira; Nozaki, Shinichi; Noguchi, Natsuyo; Kato, Koroku; Nakaya, Hiromitsu; Nakagawa, Kiyomasa
- Abstract
Background: The aim of this study was to evaluate the relationship between the expression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) in cancer cells and fibroblasts at the invasive front of oral squamous cell carcinoma (OSCC), and the pathologic and clinical characteristics. Methods: Sections of 61 biopsy specimens of primary OSCC were immunostained to assess the expression of bFGF and FGFR-1 in cancer cells and fibroblasts at the invasive front. Results: The bFGF and FGFR-1 expressions in the cancer cells were evident in all specimens, whilst, in fibroblasts, they were detected in 41 (67%) of 61 specimens. These expressions in the fibroblasts occurred notably more often in high-invasive OSCC specimens than low-invasive OSCC specimens. The prevalence of bFGF and FGFR-1 expressions in cases with lymph node metastasis was significantly higher ( P < 0.05) than in cases without metastasis. Moreover, these expressions were well correlated with patient prognosis. Conclusion: This study concludes that bFGF and FGFR-1 expressions in fibroblasts at the invasive front are linked to the mode of invasion and the prognosis in OSCC.
- Subjects
FIBROBLASTS; CANCER; CANCER invasiveness; METASTASIS; PEPTIDES; FIBROBLAST growth factors; MITOGENS; CYTOKINES
- Publication
Journal of Oral Pathology & Medicine, 2006, Vol 35, Issue 3, p136
- ISSN
0904-2512
- Publication type
Article
- DOI
10.1111/j.1600-0714.2006.00397.x