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- Title
New Cyclic Cystine Bridged Peptides from the Sponge Suberites waedoensis.
- Authors
Jinhaeng Song; Ju-eun Jeon; Tae Hyung Won; Chung J. Sim; Dong-Chan Oh; Ki-Bong Oh; Jongheon Shin
- Abstract
Two new peptides, chujamides A (1) and B (2), were isolated from the marine sponge Suberites waedoensis, which was collected from Korean waters. Based upon the results of the combined spectroscopic analyses, the structures of these compounds were determined to be proline-riched and cyclic cystine bridged dodeca- and undecapeptides. The absolute configurations of all amino acid residues were determined to be L by advanced Marfey's analysis. The new compounds exhibited weak cytotoxicities against A549 and K562 cell-lines, and compound 2 also demonstrated moderate inhibitory activity against Na+/K+-ATPase.
- Subjects
SPONGES (Invertebrates); PROLINE; PEPTIDES; CYSTINE; CYTOTOXINS
- Publication
Marine Drugs, 2014, Vol 12, Issue 9, p2760
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md12052760