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- Title
Sex-specific disparities of serum pepsinogen I in relation to body mass index.
- Authors
Xu, Wenshen; Yang, Bin; Lin, Sheng; Zhan, Fuguo; Chen, Huijuan; Qiu, Xiaoming; Liu, Can
- Abstract
The clinical significance of serum pepsinogen (PG) for screening gastric cancer has been a controversial topic. Serum PG I levels have been demonstrated to be correlated with age, sex, and the Helicobacter pylori (HP) infection. However, the underlying factors that influence serum PG I variations remain to be fully elucidated. We aimed to evaluate the impacts of sex and body mass index (BMI) on PG I in Chinese population. The cross-sectional study recruited 4,299 apparently healthy participants in Fujian Province. Serum PG levels were automatically measured using ELISA method. Serum H. pylori-IgG antibody was detected by the colloidal gold immunoassay. Clinical characteristics were obtained by questionnaire. Totally, 2,263 participants who had tests of serum PG and anti-HP IgG antibody were enrolled. Increased BMI and serum uric acid were observed in males with low PG I value (<70 μg/L). Multiple logistic regression showed the presence of overweight was the independent risk factor for male participants with low PG I level (odds ratio [OR] 1.519; p=0.017). However, the association was not found in females. Sex-specific association of serum low PG I with overweight was observed in the southeast coastal areas of China. Thus, effects of sexual dimorphism should not be ignored during the clinical utilization of serum PG I.
- Subjects
FUJIAN Sheng (China); CHINA; BODY mass index; PEPSINOGEN; COLLOIDAL gold; SEXUAL dimorphism; CHINESE people; IMMUNOGLOBULINS
- Publication
Clinical Chemistry & Laboratory Medicine, 2023, Vol 61, Issue 11, p2010
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm-2023-0236