We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hematobiochemical changes of lead Poisoning and amelioration with Ocimum sanctum in wistar albino rats.
- Authors
Karamala, Sujatha K.; Sri latha ch; Anjaneyulu Y.; Rao T.S., Chandra Sekhara; Vasulu D., Sreeni; Pidugu, Amravathi P.
- Abstract
An experiment was carried out to study the hematobiochemical changes of chronic lead poisoning in adult male wistar albino rats for a period of twelveweeks. Adult 216 healthy rats were randomly divided into six groups viz. control (groupI), higher dose of lead acetate @60mgs/kg bwt (group II), Lower dose of lead acetate@30mgs /kg bwt (group III), Higher dose of lead +Ocimum @400 mgs/ kg bwt (group IV), lower dose of lead +Ocimum @ 400 mgs/ kg bwt (group V), Ocimum control (group VI). All lead treated and ameliorated groups given Lead acetate/ lead + Ocimum orally for three days in a week for a period of twelve weeks. The mean PCV, Hb, values were reduced significantly (P<0.05) in lead treated rats as dose dependent manner. Where as significant improvement was noticed inOcimum treated groups Increased TLC and PLC values as dose dependent manner. A significant reduction in PNC was noticed in ocimum treated groups. Significant (P<0.05) decrease in serum total protein values, serum glucose and increased creatinine values were observed in lead treated groups as dose dependent . Increased protein&glucose and decreased creatinine values obtained in Ocimum treated groups. The alterations in hematological and biochemical parameters in the present study indicates decreased lifespan & fragility of RBCand damage to liver, kidney and Pancreas in lead poisonedwistar albino rats.
- Subjects
LEAD poisoning in animals; OCIMUM sanctum; LABORATORY rats; POISONING in animals; MEDICINAL plant use in animals; VETERINARY medicine
- Publication
Veterinary World, 2011, Vol 4, Issue 6, p260
- ISSN
0972-8988
- Publication type
Article
- DOI
10.5455/vetworld.4.260