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- Title
The Synaptic Remodeling Between Regenerated Perforant Pathway and Granule Cells in Slice Culture.
- Authors
Dong-ming Yu; Wen-chun Tang; Ping Wu; Tong-xing Deng; Bin Liu; Ming-shan Li; Jin-bo Deng
- Abstract
In order to understand the synaptic remodeling in the course of axonal regeneration, the synaptic remodeling of the perforant path in hippocampus was investigated in the present study with entorhino-hippocampal coculture, DiIDiOlistic assay and transmission electron microscopy. The results showed that the regeneration of the perforant pathway occurred in entorhino-hippocampal slice coculture, and putative synaptic contacts formed between the regenerated fibers and dendritic spines of granule cells. Ultrastructural analysis confirmed the formation of new synaptic contacts. In conclusion, the synaptic formation implicated in the neuroregeneration could integrate into the network in CNS.
- Publication
Cellular & Molecular Neurobiology, 2010, Vol 30, Issue 2, p309
- ISSN
0272-4340
- Publication type
Article
- DOI
10.1007/s10571-009-9454-7