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- Title
Significance of Beta-Band Oscillations in Autism Spectrum Disorders During Motor Response Inhibition Tasks: A MEG Study.
- Authors
Moliadze, Vera; Brodski-Guerniero, Alla; Schuetz, Magdalena; Siemann, Julia; Lyzhko, Ekaterina; Schlitt, Sabine; Kitzerow, Janina; Langer, Anne; Kaiser, Jochen; Naumer, Marcus J.; Wibral, Michael; Chan, Jason; Freitag, Christine M.; Siniatchkin, Michael
- Abstract
In Autism Spectrum Disorders (ASD), impaired response inhibition and lack of adaptation are hypothesized to underlie core ASD symptoms, such as social communication and repetitive, stereotyped behavior. Thus, the aim of the present study was to compare neural correlates of inhibition, post-error adaptation, and reaction time variability in ASD and neuro-typical control (NTC) participants by investigating possible differences in error-related changes of oscillatory MEG activity. Twelve male NTC (mean age 20.3 ± 3.7) and fourteen male patients with ASD (mean age 17.8 ± 2.9) were included in the analysis. Subjects with ASD showed increased error-related reaction time variability. MEG analysis revealed decreased beta power in the ASD group in comparison to the NTC group over the centro-parietal channels in both, the pre-stimulus and post-response interval. In the ASD group, mean centro-parietal beta power negatively correlated with dimensional autism symptoms. In both groups, false alarms were followed by an early increase in temporo-frontal theta to alpha power; and by a later decrease in alpha to beta power at central and posterior sensors. Single trial correlations were additionally studied in the ASD group, who showed a positive correlation of pre-stimulus beta power with post-response theta, alpha, and beta power, particularly after hit trials. On a broader scale, the results deliver important insights into top-down control deficits that may relate to core symptoms observed in ASD.
- Subjects
AUTISM spectrum disorders; RESPONSE inhibition; MOVEMENT disorders; REACTION time; OSCILLATIONS; ORTHOKERATOLOGY; APOMORPHINE
- Publication
Brain Topography, 2020, Vol 33, Issue 3, p355
- ISSN
0896-0267
- Publication type
Article
- DOI
10.1007/s10548-020-00765-6