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- Title
Clinical and pathological significance of Homo sapiens ceramide synthase 2 (CerS-2) in diverse human cancers.
- Authors
Qian Zhang; Jin-yan Wang; Wei Yan; Dan-dan Wang; Su-jin Yang; Si-ying Zhou; Shan-liang Zhong; Jin-hai Tang
- Abstract
Homo sapiens ceramide synthase 2 (CerS-2) plays an important role in inhibiting invasion and metastasis of tumor cells and has been reported as a tumormetastasis suppressor gene in diverse cancers. Thus, low level of CerS-2 protein might suggest a bad prognosis and up-regulation of CerS-2 protein might act as a promising therapeutic strategy for malignant tumors. In this review, we discussed the expression, as well as the clinical and pathological significance of CerS-2 in diverse human cancers. The pathological processes and molecular pathways regulated by CerS-2 were also summarized.
- Subjects
CERAMIDES; SYNTHASES; METASTASIS; CANCER cells; GENE expression
- Publication
Bioscience Reports, 2019, Vol 39, Issue 5, p1
- ISSN
0144-8463
- Publication type
Article
- DOI
10.1042/BSR20181743