We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Using dried blood spot for the detection of HBsAg and anti-HCV antibodies in Cameroon.
- Authors
Kenmoe, Sebastien; Tagnouokam, Paul Alain Ngoupo; Nde, Cyprien Kengne; Mella-Tamko, Ghislaine Flore; Njouom, Richard
- Abstract
Objective: Dried blood spots (DBS) offer multiple benefits for collecting, storing and shipping whole blood samples. Our objective was to compare, for the first time in Africa, the performance of DBS with respect to plasma in the detection of Hepatitis B surface antigen (HBsAg) and antibodies to Hepatitis C Virus (anti-HCV) using Architect, Abbott Diagnostics. Results: DBS had a sensitivity of 99%, a specificity of 100%, a positive predictive value of 99%, a negative predictive value of 100% and a kappa index of 0.99 for the detection of HBsAg. For anti-HCV detection, the sensitivity, specificity, positive predictive value, negative predictive value and kappa index were 99%, 98%, 98%, 99%, and 0.97, respectively. This study confirms that DBS may be a reliable alternative specimen type for HBV and HCV diagnosis.
- Subjects
HEPATITIS associated antigen; HEPATITIS C diagnosis; VIRAL antibodies; BLOOD collection; ABBOTT Diagnostics Inc.
- Publication
BMC Research Notes, 2018, Vol 11, Issue 1, p1
- ISSN
1756-0500
- Publication type
Article
- DOI
10.1186/s13104-018-3931-3