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- Title
Expression of Cyclin E and Its Related Proteins in Gestational Trophoblastic Disease.
- Authors
LI Na; QU Peng-peng
- Abstract
Objective: To investigate the expression of Cyclin E,CDK-2 and their inhibitors P27KIPI and P21WAFI/CIPI in gestational trophoblastic disease (GTD). Methods: Expression of the above indexes were determined immunohistochemically by specific antibodies for these proteins on formalin-fixed paraffin sections of 30 of normal placenta tissues, 38 of hydatidiform moles and 9 of gestational trophoblastic neoplasms (GTN), including 8 invasive moles and 1 choriocarcinoma. Results: ①The expression of Cyclin E and CDK-2 in GTD was significantly higher than that in normal placentas (P<0.01). The expression of P27KIPI and P21WAFI/CIPI in GTN was significantly lower than that in hydatidiform moles and normal placenta tissues, respectively (P<0.05). Moreover, the expression of P27KIPI and P21WAFI/CIPI in hydatidiform moles which developed GTN was significantly lower than those spontaneously regressed. ② Significant negative correlations between the Cyclin E and P27KIPI, P21WAFI/CIPI staining indexes were observed (P<0.05). There was a positive correlation between the expression of CDK-2 and Cyclin E (P<0.05). Also, the expression of P27WAFI/CIPI and P21WAFI/CIPI showed positive correlation (P<0.05). CDK-2 showed inverse expression pattern compared with P27KIPI and P21WAFI/CIPI, but no statistical difference was observed (P>0.05). Conclusions: Disregulation of Cyclin E/CDK-2 complex and its inhibitors participated in the development of gestational trophoblastic tumor. P27KIPI and P21WAFI/CIPI may be used as effective indicators for the prognosis of hydatidiform moles.
- Subjects
CYCLIN E; GESTATIONAL trophoblastic disease; IMMUNOHISTOCHEMISTRY; CHORIOCARCINOMA; PLACENTA
- Publication
Journal of International Obstetrics & Gynecology, 2014, Vol 41, Issue 3, p324
- ISSN
1674-1870
- Publication type
Article