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- Title
SARS-CoV-2 infection in a pediatrics STAT1 GOF patient under Ruxolitinib therapy-a matter of balance?
- Authors
Guisado Hernández, Paloma; Blanco Lobo, Pilar; Villaoslada, Isabel; de Felipe, Beatriz; Lucena, José M.; Martín Gutierrez, Guillermo; Castro, María José; Gutiérrez Valencia, Alicia; Sánchez Codez, María Isabel; Gaboli, Mirella; Neth, Olaf; Olbrich, Peter
- Abstract
Non-stimulated STAT1 levels in CD8+ T cells before and during SARS-CoV-2 infection (A); pSTAT1 levels in CD8 + T cells pre- and post-stimulation with IFN before and during SARS-CoV-2 infection (B). In addition, serum levels of IL6, IFN , and CXCL10 were elevated during infection, supporting the ability of the patient to develop an inflammatory response even under ruxolitinib therapy. Although increased total STAT1 levels were documented, hyperphosphorylation of STAT1 was not observed during the complete follow-up, proposing ruxolitinib to be effective in controlling cytokine hyperresponsiveness typically found in STAT1 GOF patients, even in the context of SARS-CoV-2 infection.
- Subjects
STAT proteins; SARS-CoV-2; RUXOLITINIB; COVID-19; MONONUCLEAR leukocytes; INFECTION
- Publication
Journal of Clinical Immunology, 2021, Vol 41, Issue 7, p1502
- ISSN
0271-9142
- Publication type
Letter
- DOI
10.1007/s10875-021-01081-9