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- Title
Inorganic nitrate: a game changer in preventing contrast-associated acute kidney injury.
- Authors
Zoccali, Carmine; Mallamaci, Francesca
- Abstract
Contrast-associated acute kidney injury (CA-AKI) is a serious problem in coronary angiography studies, with a high incidence rate. Current interventions for CA-AKI have limited efficacy, and there is a need for new preventive measures. The NITRATE-CIN trial tested the effect of inorganic nitrate on CA-AKI in patients undergoing coronary angiography for acute coronary syndromes. The trial found that oral administration of inorganic nitrate significantly reduced the risk of CA-AKI, improved renal function, and reduced the risk of major adverse cardiac events and mortality. This innovative approach may lead to a new standard in preventing CA-AKI.
- Subjects
ACUTE kidney failure; NITRATE reductase; ARGININE; KIDNEY transplantation; NITRATES
- Publication
European Heart Journal, 2024, Vol 45, Issue 18, p1659
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/eurheartj/ehae094