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- Title
Long-term risk for atrial and ventricular arrhythmias: a cardinal manifestation of 'the epileptic heart'.
- Authors
Verrier, Richard L; Pang, Trudy D; Schachter, Steven C
- Abstract
In recent years, evidence has been mounting that cardiac pathology is a major factor in sudden premature death in epilepsy.[1],[5],[6] Numerous investigators have reported cardiovascular comorbidities in 62%-82% of patients with epilepsy. Graph: Graphical Abstract Conceptual framework of the link between chronic epilepsy and development of an "epileptic heart" condition due to cardiotoxic effects of catecholamines, repeated hypoxaemia, with increased cardiac electrical instability manifest as T-wave alternans, a repeating ABAB beat-to-beat pattern in the ST-segment and T wave of the ECG, and atrial and ventricular arrhythmias.[1] Certain antiseizure medications (ASMs) with sodium channel-blocking properties and enzyme-inducing actions can promote both proarrhythmia and hyperlipidaemia.[2] The ECG tracings were obtained from a case report of a 51-year-old woman admitted to the epilepsy monitoring unit for video-EEG monitoring who developed ventricular fibrillation following right temporal lobe seizure that required electrical defibrillation.[3] This editorial refers to "Epilepsy and long-term risk of arrhythmias", by J. Wang I et al i . https://doi.org/10.1093/eurheartj/ehad523. Google Scholar OpenURL Placeholder Text WorldCat 10 Zack M, Luncheon C. Adults with an epilepsy history, notably those 45-64 years old or at the lowest income levels, more often report heart disease than adults without an epilepsy history.
- Subjects
EPILEPSY; DISEASE risk factors; VENTRICULAR arrhythmia; PEOPLE with epilepsy; HEART; TEMPORAL lobe epilepsy; NOSOLOGY
- Publication
European Heart Journal, 2023, Vol 44, Issue 35, p3383
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/eurheartj/ehad524