We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Association Analysis between ACE and ACTN3 Genes Polymorphisms and Endurance Capacity in Young Cross-Country Skiers: Longitudinal Study.
- Authors
Mägi, Agnes; Unt, Eve; Prans, Ele; Raus, Liina; Eha, Jaan; Veraksitš, Alar; Kingo, Külli; Kõks, Sulev
- Abstract
Endurance performance depends on the integration of several phenotypic traits influenced by multiple environmental and genetic factors. Objectives of the study were: (1) to examine the genotypic frequencies of the ACE I/D, ACTN3 R577X polymorphisms and endurance performance-related phenotypes, (2) to evaluate the dynamics of endurance performance parameters during a 5-year period in relation to ACE I/D and ACTN3 R577X genotypes in Estonian young skiers. Determination of VO2peak was performed in 58 skiers aged 15-19 years (41 males, 17 females) during a 5-year period. The control group consisted of 322 healthy non-athletic subjects (145 males, 177 females). The study groups were genotyped for the ACE I/D and ACTN3 R577X variants. Frequencies of the ACE ID and ACTN3 RR genotypes were significantly higher (p = 0.047 and p = 0.003, respectively) and the RX genotype was lower (p = 0.008) in young male skiers compared with controls. A significant relationship was found between change (Δ) of training volume and ΔVO2peak (mL⋅kg-1⋅min-1) (r = 0.475, p = 0.002). No significant main effect was detected between VO2peak (mL⋅kg-1⋅min-1) dynamics (comparison with the previous age group data) and ACE I/D and ACTN3 R577X genotypes interactions (F = 0.571, p = 0.770 and F = 0.650 and p = 0.705, respectively) in all young skiers. Study results indicated a significantly higher frequency of the ACE ID and ACTN3 RR genotypes among Estonian young male skiers compared with the male control group. Significant genotype-related differences in dynamics of VO2peak during a 5-year period were not found. In the future, longitudinal research including different gene variants may contribute to a better understanding of the nature of endurance performance.
- Subjects
ESTONIA; ANALYSIS of variance; ANTHROPOMETRY; ATHLETIC ability; CARDIOPULMONARY system; CHI-squared test; COMPARATIVE studies; STATISTICAL correlation; CROSS-country skiing; EXERCISE physiology; EXERCISE tests; GENETIC polymorphisms; HEART rate monitoring; LONGITUDINAL method; PHYSICAL fitness; PROBABILITY theory; RESEARCH funding; PHENOTYPES; STATISTICAL significance; TREADMILLS; OXYGEN consumption; DATA analysis software; DESCRIPTIVE statistics; GENOTYPES
- Publication
Journal of Sports Science & Medicine, 2016, Vol 15, Issue 2, p287
- ISSN
1303-2968
- Publication type
Article