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- Title
Studies of Monoclonal Antibodies Specific for Major Histocompatibility Complex Products of the Rat I. Production and Characterization of Monoclonal Antibodies.
- Authors
Hemmi, S.; Fenner, M.; Binz, H.; Winterhalter, K.; Wigzell, H.
- Abstract
Sixteen monoclonal antibodies against antigens coded for by the RT1 complex of the rat have been produced. Fourteen are specific for the a haplotype: six recognize class II and eight class I antigens. Two are specific for the 1 haplotype one reacting with class I and the other with class II antigens. By means of these monoclonal antibodies four independent clusters of antigens for class I antigens of the a haplotype and three for class II antigens could be defined. The three antigenic sites of class 11 antigens reside on the same heterodimer. The monoclonals described here are characterized with regard to Ig class and subclass, pI, and complement-activating capacity.
- Subjects
MONOCLONAL antibodies; IMMUNOGLOBULINS; MAJOR histocompatibility complex; IMMUNOGENETICS; ANTIGENS; IMMUNITY; TRANSPLANTATION immunology
- Publication
Scandinavian Journal of Immunology, 1985, Vol 21, Issue 6, p549
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1985.tb01845.x