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- Title
The Effect of Anti-la Antibody on Immunoglobulin-secreting Cells from Healthy Individuals and Myeloma Patients.
- Authors
Nagai, K.; Nagai, T.; Takatsuki, K.; Uchino, H.
- Abstract
Immunoglobulin-secreting cells (ISC) in the peripheral blood of healthy individuals and in the bone marrow, peripheral blood, or plasmacytomas of patients with multiple myeloma were enumerated by a protein-A plaque-forming cell assay after treatment with anti-1a antibody and complement. Rabbit anti-human B-cell antisera and monoclonal anti-1a antibody (OKIa1) were used. By this treatment, the number of ISC in the peripheral blood of healthy individuals decreased to half, and that of M-protein-secreting cells from some patients with multiple myeloma also decreased markedly. In one patient, the number of M-protein-secreting cells in the bone marrow were markedly reduced by this treatment, but this was not the case after 6 months of chemotherapy, suggesting that the chemotherapy reduced chiefly the Ia-positive myeloma cells rather than Ia-negative myeloma cells.
- Subjects
IMMUNOGLOBULINS; PLASMA cells; CELLS; MULTIPLE myeloma; BONE marrow
- Publication
Scandinavian Journal of Immunology, 1982, Vol 15, Issue 6, p567
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1982.tb00685.x