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- Title
The role of t cells in oral and pharyngeal intractable recurrent ulcers
- Authors
Inagi, Katsuhide; Nakajima, Masami; Hasumi, Keiko; Okamoto, Makito
- Abstract
Problem: The etiology and clinical definition of intractable recurrence ulcer (IRU) of the oral cavity and pharynx were unknown. The intractable recurrent ulcer of the oral cavity and pharynx was then defined as irregular ulcerative lesions occurring mainly in the oral cavity and pharynx, showing no specific findings in clinicohematological examinations, which recurred easily and were resistant to various treatments for at least 1 month. Histological examinations of these lesions have been performed for several years at our institute. Our previous study presented that apoptosis was observed in the epithelium around ulcers using the TUNEL method. Moreover the expressions of Fas were observed in epithelium around ulcers. The Fas and Fas-ligand reaction might play an important role in developing the intractable recurrent ulcer of the oral cavity and pharynx. However, the existence and localization of Fas-L have still not been understood. In this study, existences of the target memory T cells around ulcers were analyzed.Methods: Twenty patients (15 males and 5 females) with intractable recurrent ulcers of the oral cavity and pharynx were examined immunohistologically by using antihuman anti-T cell (CD45RO, UCHL1), anti-B cell (CD20/cy, L26), and anti-HLA-DR (Alpha-Chain, TAL 1B5) for detecting subclass of lymphocytes. Anti CD4, CD8, CD25, and CCR6 were used for detecting target memory T cells.Results: Eighteen of 20 IRU patients presented larger amounts of anti-T expressed cells comparing with anti-B expressed cells. Anti-HLA-DR expressed T cells were observed in both the epithelium and submucosa around ulcers. Moreover Langerhans’s cells were observed in submucosa.Conclusion: Our results suggested that the immunoactivity induced by T cells might play an important role in developing the intractable recurrent ulcer of the oral cavity and pharynx. Target memory T cell was classified as the expression of CD8, CD25, and CCR6. The Fas ligand-expressed target memory T cell might be a key cell for developing epithelial apoptosis induced by Fas and Fas ligand reaction.Significance: Immunoactivity, such as the reaction between the Fas in epithelium and the Fas-L on target memory T cell, might be one of the important roles in developing intractable recurrent ulcer of the oral cavity and pharynx.Support: None reported.
- Subjects
T cells; APOPTOSIS; EPITHELIUM; CELL death
- Publication
Otolaryngology-Head & Neck Surgery, 2004, Vol 131, Issue 2, pP198
- ISSN
0194-5998
- Publication type
Abstract
- DOI
10.1016/j.otohns.2004.06.370