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- Title
Candidate gene polymorphisms and the risk for pregnancy-related venous thrombosis.
- Authors
Dahm, Anders E. A.; Bezemer, Irene D.; Bergrem, Astrid; Jacobsen, Anne F.; Jacobsen, Eva M.; Skretting, Grethe; Rosendaal, Frits R.; Sandset, Per Morten
- Abstract
Venous thrombosis ( VT) is one of the leading causes of maternal death in the western world, but the genetic causes of pregnancy-related VT are insufficiently understood. The aim of this study was to investigate the association between common genetic variations in candidate genes and pregnancy-related VT. We undertook a hospital based case-control study of women with VT during pregnancy or puerperium; controls were women giving birth without having VT. Single nucleotide polymorphisms ( SNPs) were selected in 49 pre-specified candidate genes involved in coagulation, inflammation, and hormonal metabolism in 313 cases and 353 controls. We found new associations between SNPs and total pregnancy-related VT in the genes encoding coagulation factors V and VIII, and p-selectin. Additional new associations between SNPs and antenatal VT were found in the genes encoding the epidermal growth factor receptor, the pregnane X receptor, and protein S. Of 21 SNPs previously associated with thrombotic disease, rs2289252 in F11 and rs3917643 in F3 were associated with pregnancy-related VT, while rs4524 in F5 was associated with antenatal VT.
- Subjects
PHYSIOLOGY; OBSTETRICS; CONCEPTION; PREGNANCY; GENETIC polymorphisms; PROTEIN S deficiency; THROMBOSIS
- Publication
British Journal of Haematology, 2012, Vol 157, Issue 6, p753
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2012.09121.x