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- Title
Risk of progression in smouldering myeloma and monoclonal gammopathies of unknown significance: comparative analysis of the evolution of monoclonal component and multiparameter flow cytometry of bone marrow plasma cells.
- Authors
Pérez-Persona, Ernesto; Mateo, Gema; García-Sanz, Ramón; Mateos, María-Victoria; de las Heras, Natalia; de Coca, Alfonso García; Hernández, José M.; Galende, Josefina; Martín-Nuñez, Guillermo; Bárez, Abelardo; Alonso, José M.; Martín, Alejandro; López-Berges, Consuelo; Orfao, Alberto; San Miguel, Jesús F.; Vidriales, María-Belén
- Abstract
The present study explored the impact of two novel criteria; having >95% abnormal plasma cells by flow cytometry at diagnosis and the evolving subtype of the disease, as predictors of progression in 61 smouldering multiple myeloma (SMM) and 311 monoclonal gammopathy of unknown significance (MGUS) patients. Although both criteria were of prognostic value, the risk of progression was better identified by immunophenotyping [Hazard Ratio (HR) 6·2 and 17·2 for SMM and MGUS, respectively] than evolving subtype, which had independent prognostic value only in MGUS (HR 3·6). Immunophenotyping discriminated the different risk of progression within the evolving and non-evolving subgroups of SMM ( P = 0·01) and MGUS ( P < 0·001).
- Subjects
PLASMA cell diseases; COMPARATIVE studies; CYTOMETRY; MULTIPLE myeloma; IMMUNOPHENOTYPING
- Publication
British Journal of Haematology, 2010, Vol 148, Issue 1, p110
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2009.07929.x