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- Title
Refractory immune thrombocytopenic purpura: current strategies for investigation and management.
- Authors
Psaila, Bethan; Bussel, James B.
- Abstract
There is currently no consensus on how best to manage refractory immune thrombocytopenic purpura (ITP). In part, this reflects the need for individualized treatment due to the wide spectrum of patients' requirements and responsiveness to therapies. The objective of this review is to provide a clinically useful guide to current management strategies. This article suggests investigations to identify factors that may exacerbate thrombocytopenia and underlie poor therapeutic responses, and highlights emerging therapies, including the thrombopoietic agents, which are anticipated to dramatically alter the natural history of “refractory” ITP. Morbidity, mortality and heath-related quality of life are also discussed.
- Subjects
THROMBOTIC thrombocytopenic purpura; HEMOLYTIC anemia; BLOOD platelet disorders; BLOOD diseases; THROMBOCYTOPENIA
- Publication
British Journal of Haematology, 2008, Vol 143, Issue 1, p16
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2008.07275.x