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- Title
Analysis of T-cell repertoire and mixed chimaerism in a patient with aplastic anaemia after allogeneic bone marrow transplantation.
- Authors
Tsutsumi, Yutaka; Tanaka, Junji; Sugita, Junichi; Kato, Naoko; Zhang, Li; Yonezumi, Masakatsu; Chiba, Kouji; Toyosima, Nobuyasu; Kondo, Takeshi; Ohta, Shuichi; Mori, Akio; Hasino, Satoshi; Asaka, Masahiro; Imamura, Masahiro
- Abstract
Summary. We analysed 26 T-cell receptor (TCR) β chain subfamilies (VB) of a patient with aplastic anaemia (AA) who underwent allogeneic bone marrow transplantation (allo-BMT). The patient developed pancytopenia at d 80. The patient's T cells were skewed in 10 of 26 TCR-VB on d 83. These TCR-VB, especially VB15, which were almost entirely CD8-positive cells, were skewed throughout her clinical course. Chimaerism analysis of the CD8-positive cells indicated that they were of recipient origin. Therefore, some immune responses induced by the recipient CD8-positive T cells had an important role in pancytopenia in AA patients after allo-BMT.
- Subjects
BONE marrow transplantation; T cells; APLASTIC anemia; GRAFT rejection
- Publication
British Journal of Haematology, 2002, Vol 118, Issue 1, p136
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2002.03628.x