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- Title
Engraftment of T-cell-depleted allogeneic haematopoietic stem cells using a reduced intensity conditioning regimen.
- Authors
Craddock, C.; Bardy, P.; Kreiter, S.; Johnston, R.; Apperley, J.; Marks, D.; Huber, C.; Kolbe, K.; Goulding, R.; Lawler, M.; Goldman, J.; Hughes, T.; Derigs, G.
- Abstract
Graft-versus-host disease (GVHD) remains a significant complication in patients undergoing allogeneic stem cell transplantation (SCT) using a reduced intensity conditioning regimen. Although T-cell depletion (TCD) reduces the risk of GVHD after a myeloablative conditioning regimen, it is associated with an increased risk of graft failure. We have therefore examined whether TCD compromises engraftment using a fludarabine-based conditioning regimen. Fifteen patients have been transplanted using such a regimen of whom 13 underwent ex vivo TCD. All but one patient demonstrated durable engraftment and no patient receiving a TCD product developed severe GVHD. Thus, TCD may play a role in GvHD prophylaxis using such regimens.
- Subjects
T cells; HEMATOPOIETIC stem cells; GRAFT versus host disease; COMPLICATIONS from organ transplantation; FLUDARABINE
- Publication
British Journal of Haematology, 2000, Vol 111, Issue 3, p797
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2000.02454.x