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- Title
Tert‐Butylnitrite Mediated Regioselective C(sp<sup>2</sup>)−3 Nitration of Substituted 4‐Quinolones and Its Late‐stage Manipulations.
- Authors
Ghosh, Prasanjit; Chhetri, Gautam; Mandal, Anirban; Mahato, Manas; Das, Sajal
- Abstract
A novel and eco‐friendly technique for the synthesis of C‐3 nitro derivatives of 4‐quinolones via the regioselective C(sp2)−H bond functionalization employing tert‐butyl nitrite as nitrating agent in presence of TEMPO [(2,2,6,6‐tetramethylpiperidin‐1‐yl)oxyl] as an oxidant is unfolded herein. The protocol is scalable as well as high yielding with wide substrate scope and broad functional group tolerance. In‐depth mechanistic investigations revealed that the reaction occurred through a free radical pathway. The nitro derivatives of 4‐quinlones were selectively reduced to corresponding aminated 4‐quinolones. Finally, the photophysical properties of synthesized amine derivatives were also investigated, and some of them showed good fluorescence properties.
- Subjects
NITRATION; FREE radicals; AMINE derivatives; FUNCTIONAL groups; RADICALS (Chemistry)
- Publication
Asian Journal of Organic Chemistry, 2023, Vol 12, Issue 9, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202300286