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- Title
Pd‐Catalyzed Chemoselective Bis‐Allylic Substitution of Allylic Dicarbonates with Arylated Nitromethanes: A Route to 1,2‐Oxazine N‐Oxides.
- Authors
Zhao, Can; Li, Tao; Khan, Ijaz; Zhang, Yong Jian
- Abstract
An efficient method for the construction of 1,2‐oxazine N‐oxides has been developed via Pd‐catalyzed chemoselective bis‐allylic substitution of 2‐methylenepropane‐1,3‐diol dicarbonates with arylated nitroalkanes through sequential C‐ and O‐nucleophilic allylic substitution in one‐pot manipulation. By using Pd(PPh3)4 as a catalyst under mild reaction conditions, the process allows rapid access to 3‐aryl‐5,6‐dihydro‐4H‐1,2‐oxazine N‐oxides in high yields with excellent chemoselectivities.
- Subjects
OXAZINES; NITROALKANES; CHEMOSELECTIVITY; CATALYSTS
- Publication
Asian Journal of Organic Chemistry, 2022, Vol 11, Issue 4, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202200065