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- Title
Dual Roles of α,β‐Unsaturated Oximes in Copper Catalyzed [3+3] Cyclization: Construction of 2,4,6‐Trisubstituted Pyridines.
- Authors
Liu, Jianming; Zhao, Shufang; Yan, Xuyang; Wang, Zhixian; Zhang, Yanyan; Zhao, Peizheng; Fang, Wenhan; Zhuo, Kelei; Yue, Yuanyuan
- Abstract
Abstract: A new approach to generate 2,4,6‐trisubstituted pyridines was successfully developed based on the cyclization of α,β‐unsaturated oximes catalyzed by copper(I). The method takes advantage of the inherent properties of α,β‐unsaturated oximes to generate pyridines. In this transformation, α,β‐unsaturated oximes play dual roles in the formation of nucleophilic copper(II) enamide and as the acceptor in the Michael addition.
- Subjects
OXIMES; COPPER catalysts; RING formation (Chemistry); PYRIDINE synthesis; MICHAEL reaction
- Publication
Asian Journal of Organic Chemistry, 2018, Vol 7, Issue 8, p1565
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.201800318