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- Title
Pharmacological Management of Trans and Gender-Diverse Adolescents.
- Authors
O'Connell, Michele A.; Nguyen, Thomas P.; Ahler, Astrid; Skinner, S. Rachel; Pang, Ken C.
- Abstract
Internationally, increasing numbers of children and adolescents with gender dysphoria are presenting for care. In response, gender-affirming therapeutic interventions that seek to align bodily characteristics with an individual's gender identity are more commonly being used. Depending on a young person's circumstances and goals, hormonal interventions may aim to achieve full pubertal suppression, modulation of endogenous pubertal sex hormone effects, and/or development of secondary sex characteristics congruent with their affirmed gender. This is a relatively novel therapeutic area and, although shortterm outcomes are encouraging, longer term data from prospective longitudinal adolescent cohorts are still lacking, which may create clinical and ethical decision-making challenges. Here, we review current treatment options, reported outcomes, and clinical challenges in the pharmacological management of trans and gender-diverse adolescents.
- Subjects
TRANSGENDER youth; ETHICAL decision making; GENDER dysphoria; SEXUAL dimorphism; TEENAGERS; GENDER identity; TEENAGE girls
- Publication
Journal of Clinical Endocrinology & Metabolism, 2022, Vol 107, Issue 1, p241
- ISSN
0021-972X
- Publication type
Article
- DOI
10.1210/clinem/dgab634