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- Title
Causal Effects of N-6 Polyunsaturated Fatty Acids on Age-related Macular Degeneration: A Mendelian Randomization Study.
- Authors
Kai Wang; Yueyang Zhong; Fangkun Yang; Chenyang Hu; Xin Liu; Yanan Zhu; Ke Yao; Wang, Kai; Zhong, Yueyang; Yang, Fangkun; Hu, Chenyang; Liu, Xin; Zhu, Yanan; Yao, Ke
- Abstract
<bold>Context: </bold>Although the role of n-6 polyunsaturated fatty acids (PUFAs) in age-related macular degeneration (AMD) has been studied in previous observational studies, the precise manner in which 1 or more n-6 PUFAs account for this relationship remains unclear.<bold>Objective: </bold>Using genetic instruments for n-6 PUFAs traits implemented through mendelian randomization (MR), we aimed to study possible causal associations between n-6 PUFAs and AMD.<bold>Methods: </bold>The 2-sample MR method was used to obtain unconfounded causal estimates. We selected genetic variants strongly associated (P < 5 × 10-8) with circulating linoleic acid (LA) and arachidonic acid (AA) from a study involving 8 631 individuals and applied to an AMD case-control study (33 526 participants and 16 144 cases). The weighted median and MR Egger methods were used for the sensitivity analysis.<bold>Results: </bold>Our MR analysis suggested that circulating LA was a causal protective factor for AMD, with an odds ratio (OR) estimate of 0.967 (95% CI 0.945 to 0.990; P = .005) per percentage in total fatty acid increase in LA. In contrast, higher genetically predicted circulating AA causally increased the AMD risk (OR = 1.034; 95% CI 1.012 to 1.056; P = .002). Sensitivity analysis provided no indication of unknown pleiotropy. The findings from different single-nucleotide polymorphism selections and analytic methods were consistent, suggesting the robustness of the causal associations.<bold>Conclusion: </bold>Our study provided genetic evidence that circulating LA accounted for protective effects of n-6 PUFAs against the risk of AMD, whereas AA was responsible for deleterious effects on higher AMD risk.
- Subjects
OMEGA-6 fatty acids; UNSATURATED fatty acids; MACULAR degeneration; DISEASE risk factors; OMEGA-3 fatty acids; LEUCOCYTES
- Publication
Journal of Clinical Endocrinology & Metabolism, 2021, Vol 106, Issue 9, pe3565
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/clinem/dgab338