We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of α-Fluoromethylhistidine on the Histamine Content of the Brain of W/W<sup>v</sup> Mice Devoid of Mast Cells: Turnover of Brain Histamine.
- Authors
Maeyama, Kazutaka; Watanabe, Takehiko; Yamatodani, Atsushi; Taguchi, Yoshitaka; Kambe, Hiroshi; Wada, Hiroshi
- Abstract
In the brains of W/Wv mutant mice that have no mast cells, the histidine decarboxylase (HDC) level is as high as in the brain of congenic normal mice (+/+), but the histamine content is 53% of that of +/+ mice. The effects of a-fluoromethylhistidine (α-FMH) on the HDC activity and histamine content of the brain of W/Wr and +/+ mice were examined. In both strains, 30 min after i.p. injection of α-FMH the HDC activity of the brain had decreased to 10% of that in untreated mice. The histamine content decreased more gradually, and after 6 h about half of the control level remained in +/+ mice, whereas histamine had disappeared almost completely in W/Wv mice. It is concluded that the portion of the histamine content that was depleted by HDC inhibitor in a short time is derived from non-mast cells, probably neural cells. The half-life of histamine in the brain of W/Wv mice was estimated from the time-dependent decrease in the histamine content of the brain after administration of a-FMH: 48 min in the forebrain, 103 min in the midbrain, and 66 min in the hindbrain.
- Publication
Journal of Neurochemistry, 1983, Vol 41, Issue 1, p128
- ISSN
0022-3042
- Publication type
Article
- DOI
10.1111/j.1471-4159.1983.tb11823.x