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- Title
Injectable nanocurcumin-dispersed gelatin–pluronic nanocomposite hydrogel platform for burn wound treatment.
- Authors
Dang, Le Hang; Huynh, Ngoc Trinh; Pham, Ngoc Oanh; Nguyen, Cong Truc; Vu, Minh Thanh; Dinh, Van Thoai; Le, Van Thu; Tran, Ngoc Quyen
- Abstract
To utilize the potent pharmaceutical properties of curcumin (Cur) and gelatin-based materials in tissue regeneration, we fabricated a thermosensitive nanocomposite hydrogel based on pluronic-grafted gelatin (PG) and nanocurcumin (nCur) to enhance burn healing. In this method, the amphiphilic PG played a role as a surfactant to prepare and protect nanosized Cur particles, which could overcome the poor dissolution of the phytochemical. The synthesized PG was identified by 1 H nuclear magnetic resonance. Depending on the amount of Cur, size distribution of the dispersed nCur ranged from 1.5 ± 0.5 to 16 ± 3.2 nm as observed using transmission electron microscopy and dynamic light scattering. The nCur-dispersed PG solution formed nCur–PG nanocomposite hydrogel on warming up to 35 ∘ C . Release profile indicated sustainable release of Cur from the injectable platform. Fibroblast cells were well proliferated on the nanocomposite hydrogel. The nCur–PG enhanced the healing process of second-degree burn wound. These results showed potential applications of the biomaterial in tissue regeneration.
- Subjects
BIOMATERIALS; HYDROGELS; NUCLEAR magnetic resonance; NANOPARTICLES; TRANSMISSION electron microscopy; LIGHT scattering; MICROSCOPY
- Publication
Bulletin of Materials Science, 2019, Vol 42, Issue 2, pN.PAG
- ISSN
0250-4707
- Publication type
Article
- DOI
10.1007/s12034-019-1745-0