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- Title
Serum lnc34a is a potential prediction biomarker for bone metastasis in hepatocellular carcinoma patients.
- Authors
Zhang, Li; Niu, Hao; Yang, Ping; Ma, Jie; Yuan, Bao-Ying; Zeng, Zhao-Chong; Xiang, Zuo-Lin
- Abstract
<bold>Background: </bold>Early screening and intervention therapies are crucial to improve the prognosis of hepatocellular carcinoma (HCC) patients with bone metastasis. We aimed to identify serum lncRNA as a prediction biomarker in HCC bone metastasis.<bold>Methods: </bold>The expression levels of lnc34a in serum samples from 157 HCC patients were detected by quantitative real-time polymerase chain reaction (PCR). Univariate analysis and multivariate analysis were performed to determine statistically significant variables.<bold>Results: </bold>Expression levels of lnc34a in serum from HCC patients with bone metastasis were significantly higher than those without bone metastasis. The high expressions of lnc34a, vascular invasion and Barcelona Clinic Liver Cancer (BCLC) stage were associated with bone metastasis by analysis. Moreover, lnc34a expression was specifically associated with bone metastasis rather than lung or lymph node metastasis in HCC.<bold>Conclusions: </bold>High serum lnc34a expression was a independent risk factor for developing bone metastasis in HCC.
- Subjects
BONE metastasis; LYMPHATIC metastasis; HEPATOCELLULAR carcinoma; POLYMERASE chain reaction; LIVER cancer; SERUM
- Publication
BMC Cancer, 2021, Vol 21, Issue 1, p1
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-021-07808-6