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- Title
Regeneration of Periodontal Tissues in Non-human Primates with rhGDF-5 and Beta-Tricalcium Phosphate.
- Authors
Emerton, K.B.; Drapeau, S.J.; Prasad, H.; Rohrer, M.; Roffe, P.; Hopper, K.; Schoolfield, J.; Jones, A.; Cochran, D.L.
- Abstract
The application of growth factors has been advocated in support of periodontal regeneration. Recombinant human growth and differentiation factor-5 (rhGDF-5), a member of the bone morphogenetic protein family, has been used to encourage periodontal tissue regeneration. This study evaluated the dose response of rhGDF-5 lyophilized onto beta-tricalcium phosphate (bTCP) granules for periodontal tissue regeneration in a baboon model. Periodontal defects were created bilaterally in 12 baboons by a split-mouth design. Plaque was allowed to accumulate around wire ligatures to create chronic disease. After 2 mos, the ligatures were removed, and a notch was placed at the base of the defect. Two teeth on each side of the mouth were randomly treated with bTCP only, 0.5, 1.0, or 2.0 mg rhGDF-5/g bTCP. Animals were sacrificed 5 mos post-treatment, with micro-CT and histomorphometric analysis performed. After 5 mos, analysis showed alveolar bone, cementum, and periodontal ligament formation in all treatment groups, with a dose-dependent increase in rhGDF-5-treated groups. Height of periodontal tissues also increased with the addition of rhGDF-5, and the amount of residual graft material decreased with rhGDF-5 treatment. Therefore, rhGDF-5 delivered on bTCP demonstrated effective regeneration of all 3 tissues critical for periodontal repair.
- Subjects
REGENERATION (Biology); PERIODONTAL ligament; PRIMATES; BONE regeneration; PERIODONTAL disease; CALCIUM phosphate; LIGATURE (Surgery); BABOONS as laboratory animals; ALVEOLAR process; CEMENTUM
- Publication
Journal of Dental Research, 2011, Vol 90, Issue 12, p1416
- ISSN
0022-0345
- Publication type
Article
- DOI
10.1177/0022034511423665