We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Supplemental feeding of 1,5-anhydro-D-glucitol prevents the onset and development of diabetes through the suppression of oxidative stress in KKAy mice.
- Authors
Kenichi TANABE; Sadako NAKAMURA; Toshiyuki NAKAYAMA; Kazuhiro YOSHINAGA; Chihiro USHIRODA; Tsuneyuki OKU
- Abstract
Recently, 1,5-anhydro-D-glucitol (1,5-AG) has been manufactured using microbe-derived enzymes and we previously reported that it inhibits intestinal sucrase and maltase activity. However, its function in supplements for diabetes prevention has not been clarified. We investigated the effect feeding of 1,5-AG has of delaying the onset of diabetes through its antioxidant properties. KKAy mice were raised with an AIN93G (control), 3 % or 6 % 1,5-AG, or 6 % erythritol (ERT, positive control) diet for 7 weeks. Urinary glucose excretion in the 6 % 1,5-AG group at 4 and 6 weeks and in the 6 % ERT group at 4, 6, and 7 weeks was significantly lower than in the control group (p < 0.05). After 7 weeks, urine 8-hydroxy-2’- deoxyguanosine, fasting plasma glucose, insulin, total cholesterol, and triacylglycerol in the 6 % 1,5-AG group were lower than in the control group (p < 0.05). Feeding of 6 % 1,5-AG appears to prevent the onset of diabetes-related symptoms through its systemic antioxidant effect.
- Subjects
OXIDATIVE stress; BLOOD sugar; DIABETES; MICE; DEOXYGUANOSINE; INSULIN
- Publication
Food Science & Technology Research, 2023, Vol 29, Issue 5, p413
- ISSN
1344-6606
- Publication type
Article
- DOI
10.3136/fstr.FSTR-D-23-00037