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- Title
Isolation and characterization of adenoviruses infecting endangered golden snub-nosed monkeys (Rhinopithecus roxellana).
- Authors
Bing Tan; Li-Jun Wu; Xing-Lou Yang; Bei Li; Wei Zhang; Yong-Song Lei; Yong Li; Guo-Xiang Yang; Jing Chen; Guang Chen; Han-Zhong Wang; Zheng-Li Shi
- Abstract
Background: Adenoviruses are important pathogens with the potential for interspecies transmission between humans and non-human primates. Although many adenoviruses have been identified in monkeys, the knowledge of these viruses from the Colobinae members is quite limited. Findings: We conducted a surveillance of viral infection in endangered golden snub-nosed monkeys (Rhinopithecus roxellana) in the subfamily Colobinae in China, and found that 5.1% of sampled individuals were positive for adenovirus. One of the adenoviruses (SAdV-WIV19) was successfully isolated and its full-length genome was sequenced. The full-length genome of WIV19 is 33,562 bp in size, has a G + C content of 56.2%, and encodes 35 putative genes. Sequence analysis revealed that this virus represents a novel species in the genus Mastadenovirus. Diverse cell lines, including those of human origin, were susceptible to WIV19. Conclusion: We report the first time the isolation and full-length genomic characterization of an adenovirus from the subfamily Colobinae.
- Subjects
ADENOVIRUSES; PATHOGENIC microorganisms; GOLDEN snub-nosed monkey; DNA viruses; NUCLEOTIDE sequencing
- Publication
Virology Journal, 2016, Vol 13, Issue 1, p1
- ISSN
1743-422X
- Publication type
Article
- DOI
10.1186/s12985-016-0648-6