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- Title
Clinical Characteristics of TZAP (ZBTB48) in Hepatocellular Carcinomas from Tissue, Cell Line, and TCGA.
- Authors
Jung, Soo-Jung; Kil, So-Hyun; Lee, Hye Won; Park, Tae In; Lee, Yun-Han; Kim, Jongwan; Lee, Jae-Ho
- Abstract
Background and Objectives: ZBTB48 is a telomere-related protein that has been renamed telomeric zinc finger-associated protein (TZAP). It favorably binds to elongated telomeres to regulate their appropriate length. However, TZAP expression has not been investigated in hepatocellular carcinomas (HCC). Materials and Methods: The clinical significance of TZAP expression in 72 HCC was investigated. Additionally, its findings were supported by open big data and cancer cell lines. Results: TZAP expression level was not associated with the clinical parameters of HCC. TZAP expression induced a poorer survival result (overall survival, p = 0.020; disease-free survival, p = 0.012). TCGA data showed TZAP expression was more frequently found in HCCs with hepatitis C infection (p = 0.023). However, TCGA data revealed that TZAP expression did not predict HCC prognosis. In a cell line study, TZAP inhibition via siRNA suppressed PLC/PRF/5 cell growth; however, cell viability was increased in HepG2 cells. Conclusions: We presented the clinical and prognostic values of TZAP expression in HCC tissues and cancer cell lines. Additionally, the TCGA results also revealed a significant role for TZAP expression. TZAP expression may involve HCC progression and its prognosis.
- Subjects
HEPATOCELLULAR carcinoma; CELL lines; ZINC proteins; PROGRESSION-free survival; CELL growth
- Publication
Medicina (1010660X), 2022, Vol 58, Issue 12, p1778
- ISSN
1010-660X
- Publication type
Article
- DOI
10.3390/medicina58121778