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- Title
Correlation between leukocyte, neutrophil, lymphocyte, and the neutrophil to lymphocyte ratio levels in Mycobacterium tuberculosis detection using rapid molecular tests.
- Authors
Yusran, Andi; Hatta, Moch; Haruna, Nadyah; Natzir, Rosdiana; Agus, Rosana; Hamid, Firdaus
- Abstract
Pulmonary tuberculosis (TB) is a chronic inflammatory disease caused by Mycobacterium Tuberculosis (MTB). Rapid molecular testing (TCM) can detect MTB and simultaneously perform drug sensitization testing by identifying genetic material that represents resistance. One of the immune responses to TB is inflammation. Leukocytes, Neutrophils, Lymphocytes, and neutrophil-lymphocyte ratio (NLR) have become potential inflammatory markers to determine the presence of chronic inflammation that plays a role in the physiological immune response of TB infection. Leukocytes circulate against various stress conditions during inflammation, characterized by increased neutrophil counts and decreased lymphocyte counts. This study aims to determine the relationship between the number of leukocytes, neutrophils, lymphocytes, and NLR as biomarkers of germ detection levels with TCM in TB patients. This type of quantitative research uses analytical study methods with a cross-sectional approach, with total sampling in accordance with the exclusion and inclusion criteria with a total sample of 187 people consisting of 67 positive samples and 120 negative samples. Results show the mean value of the number of leukocytes at the detection level was High 12.20 (7.30 -18.40), Medium 10.50 (470-19.90), Low 9.35 (5.20-17.60), and Negative 8.80 (3.30-19.80). Neutrophils at detection levels were High 77.00 (53.20 - 86.90), Medium 73.15 (55.50 - 90.60), Low 71.70 (48.10 - 89.30), and Negative 65.05 (11.30 -88.80). Lymphocytes at detection levels were High at 11.40 (2.70 - 27.50), Medium at 14.55 (4.10 - 31.50), Low at 16.90 (5.00 - 44.70), and Negative at 22.05 (5.80 - 69.30). And NLR at detection levels of High 16.90 (2.27 - 21.26), Medium 5.22 (1.76 - 22.10), Low 4.30 (1.15 - 16.98), and Negative 2.90 (0.35 - 14.80). There was a significant association between leukocyte count (p=0.003), neutrophil (p=0.001), and NLR (p=0.001) with the germ detection rate using TCM. Conclusion: The number of leukocytes, neutrophils, lymphocytes, and NLR can be used as biomarkers to detect the level of germ count with TCM in TB.
- Subjects
LEUCOCYTES; NEUTROPHILS; LYMPHOCYTES; MYCOBACTERIUM tuberculosis; MOLECULAR diagnosis; TUBERCULOSIS diagnosis
- Publication
Gaceta Médica de Caracas, 2024, Vol 132, pS115
- ISSN
0367-4762
- Publication type
Article
- DOI
10.47307/GMC.2024.132.s1.16