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- Title
Synthesis of manganese nanoparticles of Oolong tea extract by sonication method for a natural oral contrast media on magnetic resonance cholangiopancreatography.
- Authors
Fatimah, Fatimah; Susilaningsih, Neni; Sukmaningtyas, Hermina; Subagio, Agus
- Abstract
Introduction: Magnetic resonance cholangiopancreatography examination using natural contrast media has not provided an optimal image of gastroduodenal suppression that covers the image of the biliary system. Natural materials used as contrast media continue to be developed with various previous studies, but not many have been associated with using nanoparticles as natural contrast media materials. This study aims to make manganese nanoparticles in oolong tea extract used as an oral contrast medium. Methods: In this experimental study, the extraction of oolong tea using the boiling method with 15 mL of distilled water was dissolved in 200 mL of distilled water and then sonicated with a frequency of 20 kHz with time variations of 10, 15, 20, and 25 minutes. The results of the sonication process carried out a Particle Size Analyzer (PSA) test. Furthermore, the obtained manganese nanoparticles were given orally to healthy volunteers, and a Magnetic Resonance Cholangiopancreatography (MRCP) examination was performed. Results: The resulting MRCP image measures the Signal to noise ratio (SNR) value in the stomach, duodenum, and biliary tract system. Synthesis of manganese nanoparticles with the sonication method showed that sonication for 10 minutes resulted in manganese particle sizes with a diameter of 1 364.8 nm, 15 minutes with a diameter of 1 204.7 nm, 20 minutes with a diameter of 488.2 nm, 25 minutes with a diameter of 1131.8 nm. The results with the particle size with a diameter of 488.2 nm are nanoparticles, then used for MRCP examination. Conclusion: Manganese nanoparticles from oolong tea extract can suppress objects covering the pancreatic biliary tree system, increasing contrast enhancement in the pancreato biliary tree system.
- Subjects
MANGANESE; NANOPARTICLES; CONTRAST media; ENDOSCOPIC retrograde cholangiopancreatography; PARTICLE size distribution
- Publication
Gaceta Médica de Caracas, 2022, Vol 130, pS936
- ISSN
0367-4762
- Publication type
Article
- DOI
10.47307/GMC.2022.130.s5.11