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- Title
Baseline Albumin Is Associated with Worsening Renal Function in Patients with Acute Decompensated Heart Failure Receiving Continuous Infusion Loop Diuretics.
- Authors
Clarke, Megan M.; Dorsch, Michael P.; Kim, Susie; Aaronson, Keith D.; Koelling, Todd M.; Bleske, Barry E.
- Abstract
Study Objectives To identify baseline predictors of worsening renal function ( WRF) in an acute decompensated heart failure ( ADHF) patient population receiving continuous infusion loop diuretics. Design Retrospective observational analysis. Setting Academic tertiary medical center. Patients A total of 177 patients with ADHF receiving continuous infusion loop diuretics from January 2006 through June 2009. Measurements and Main Results The mean patient age was 61 years, 63% were male, ~45% were classified as New York Heart Association functional class III, and the median length of loop diuretic infusion was 4 days. Forty-eight patients (27%) developed WRF, and 34 patients (19%) died during hospitalization. Cox regression time-to-event analysis was used to determine the time to WRF based on different demographic and clinical variables. Baseline serum albumin 3 g/dl or less was the only significant predictor of WRF (hazard ratio [HR] 2.87, 95% confidence interval [CI] 1.60-5.16, p=0.0004), which remained significant despite adjustments for other covariates. Conclusion Serum albumin 3 g/dl or less is a practical baseline characteristic associated with the development of WRF in patients with ADHF receiving continuous infusion loop diuretics.
- Subjects
HEART failure patients; KIDNEY diseases; DIURETICS; ALBUMINS; BUMETANIDE; FUROSEMIDE
- Publication
Pharmacotherapy, 2013, Vol 33, Issue 6, p583
- ISSN
0277-0008
- Publication type
Article
- DOI
10.1002/phar.1241