We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
In vitro and in vivo antileishmanial activities of a Brazilian green propolis extract.
- Authors
Karina Pontin; Ademar Da Silva Filho; Fransérgio Santos; Márcio Silva; Wilson Cunha; N. Nanayakkara; Jairo Bastos; Sérgio de Albuquerque
- Abstract
Abstract The in vitro antileishmanial activity of Brazilian green propolis hydroalcoholic extract (BPE) were carried out on Leishmania (Viannia) braziliensis against both promastigote (doses ranging from 1 to 750 μg mL−1) and amastigote (10, 100, and 250 μg mL−1) assays in comparison with the positive (amphotericin B) and negative (dimethyl sulfoxide at 1% in physiologic solution) control groups. BPE displayed in vitro antileishmanial activities against promastigote forms of the parasite (p p-coumaric acid, aromadendrine-4′-methyl-ether, 3-prenyl-p-coumaric acid (drupanin), and 3,5-diprenil-p-cumárico acid (artepillin C) as major compounds of BPE. In the in vivo assay, using a Balb/C lineage of Mus musculus male mice, groups of ten animals each were treated (1.5 mg kg day−1) with BPE orally (group 1), BPE topically (group 2), BPE orally and topically (group 3), and glucantime (group 4), using NaCl 0.9% (group 5) as the negative control group. Groups 1, 2, and 3 displayed a decrease on lesion development, after 90 days of treatment, by 78.6%, 84.3%, and 90.0%, respectively, while the glucantime-treated group showed 57.7% of decrease, all in comparison with the negative control group. It is the first time that the in vivo antileishmanial activity has been reported for Brazilian green propolis.
- Subjects
BRAZIL; PROPOLIS; LEISHMANIASIS treatment; AMPHOTERICIN B; DIMETHYL sulfoxide; BIOLOGICAL assay; PARASITOLOGICAL research; THERAPEUTICS
- Publication
Parasitology Research, 2008, Vol 103, Issue 3, p487
- ISSN
0932-0113
- Publication type
Article
- DOI
10.1007/s00436-008-0970-z