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- Title
Aerobic Asymmetric Allylic C−H Alkylation by Synergistic Chiral Primary Amine‐Palladium‐Hydroquinone Catalysis.
- Authors
Wang, Rui; Zhang, Long; Luo, Sanzhong
- Abstract
A synergistic chiral primary amine/palladium /p‐hydroquinone catalysis was developed to facilitate oxidative asymmetric allylic C−H alkylation under aerobic conditions. The ternary synergistic catalysis enables a facile allylic C−H activation and alkylation with oxygen so that stoichiometric utilization of benzoquinone can be avoided. The identified optimal catalytic system allows for terminal addition to allyl arenes with α‐branched β‐ketocarbonyls to afford allylic adducts bearing all‐carbon quaternary centers with high regio‐ and enantioselectivity. This work provides new insights for further studies on the aerobically oxidative C−H alkylation reaction.
- Subjects
ALKYLATION; CATALYSIS; ALLYLIC alkylation; BENZOQUINONES; PALLADIUM; AROMATIC compounds
- Publication
Chemistry - A European Journal, 2024, Vol 30, Issue 16, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202304316