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- Title
A Shared Prebiotic Formation of Neopterins and Guanine Nucleosides from Pyrimidine Bases.
- Authors
Menor‐Salván, César; Burcar, Bradley T.; Bouza, Marcos; Fialho, David M.; Fernández, Facundo M.; Hud, Nicholas V.
- Abstract
The prebiotic origins of biopolymers and metabolic co‐factors are key questions in Origins of Life studies. In a simple warm‐little‐pond model, using a drying phase to produce a urea‐enriched solution, we present a prebiotic synthetic path for the simultaneous formation of neopterins and tetrahydroneopterins, along with purine nucleosides. We show that, in the presence of ribose and in a formylating environment consisting of urea, ammonium formate, and water (UAFW), the formation of neopterins from pyrimidine precursors is robust, while the simultaneous formation of guanosine requires a significantly higher ribose concentration. Furthermore, these reactions provide a tetrahydropterin–pterin redox pair. This model suggests a prebiotic link in the origin of purine nucleosides and pterin cofactors that provides a possible deep prebiotic temporal connection for the emergence of nucleic acids and metabolic cofactors.
- Subjects
PYRIMIDINE nucleosides; NUCLEIC acids; ORIGIN of life; NUCLEOSIDES; RIBOSE; GUANINE; INULIN
- Publication
Chemistry - A European Journal, 2022, Vol 28, Issue 39, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202200714