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- Title
Lung Mechanics in Orally Immunized Mice after Aerolized Exposure to Influenza Virus.
- Authors
Bergmann, Karl-Christian; Lachmann, Burkhard; Noack, Klaus
- Abstract
A method is described which allows the investigation of lung mechanics during artificial ventilation in live mice. Inhalation of nebulized influenza virus (A/ PR/8/34, H1N1) decreased in NMRI mice compliance (x = 0.012 ml/cm H2O, n = 18) due to severe virus pneumonia and edema on days 5-7 after infection. In comparison to noninfected controls (x = 0.029 ml/cm H2O, n = 17) compliance was unchanged in infected, but orally immunized mice (x = 0.030 ml/cm H2O, n = 21). The results demonstrate that decreased compliance due to influenza virus pneumonia can be prevented by oral immunization with influenza viruses Copyright © 1984 S. Karger AG, Basel
- Publication
Respiration, 1984, Vol 46, Issue 2, p218
- ISSN
0025-7931
- Publication type
Article
- DOI
10.1159/000194692