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- Title
Biocompatibility of silver nitrate and ofloxacine coated bioabsorbable SR-PLLA rods.
- Authors
Multanen, Markku; Talja, Martti; Tammela, Teuvo L. J.; Seppälä, Jukka; Välimaa, Tero; Järvi, Kari; Törmälä, Pertti
- Abstract
The purpose of this study was to evaluate the biocompatibility of silver nitrate and ofloxacine coatings of bioresorbable self-reinforced poly-l-lactic acid (SR-PLLA) rods. SR-PLLA rods coated with pure poly(caprolactone-co-l-lactide) or blended with silver nitrate (10, 5 or 2 weight-%) or ofloxacine (5 or 2 weight-%) were implanted in the dorsal muscles of 25 male rabbits. Tissue reactions caused by implantation trauma were seen 1 week after implantation. The positive control and 10 w-% silver nitrate coating showed the most marked reactions 1 month after implantation. Only sparse reactions were seen 6 months after implantation. Tissue reactions were scored semi-quantitatively. As a result of this study, we concluded that silver nitrate or ofloxacine coatings up to five w-% did not alter the good biocompatibility of SR-PLLA essentially. The method may lead to the possibility of preventing bacterial adhesion to urological stents during insertion.
- Subjects
BIOCOMPATIBILITY; SILVER nitrate; LACTIC acid; BACTERIAL adhesion; CELL adhesion; SURGICAL stents
- Publication
Urological Research, 2001, Vol 29, Issue 2, p113
- ISSN
0300-5623
- Publication type
Article
- DOI
10.1007/s002400000166